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2 or MdMYB60 on the transcription of structural genes. These results imply that brassinolide decreases flavonoid contents through the MdBEH2.2-MdMYB60 regulatory module. Our findings further clarify the molecular mechanism mediating the regulation of flavonoid biosynthesis by BR signals in horticultural crops.Chronic pain affects one in five of the general population and is the third most important cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate due to poor efficacy and tolerability. There h

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