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In inclusion, an extrinsic caspase pathway activation had been noted at early time things, while enhanced variety of cleaved caspase 3+ cells might be noticed in ischemic retinae through the entire research. Retinal ischemia induced an earlier and strong microglia/macrophage response as well as cytokine and apoptotic activation procedures. More over, during the early and late ischemic damaging processes, TLR expression and downstream signaling were included, suggesting an involvement in neuronal demise
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