https://www.selleckchem.com/pr....oducts/jr-ab2-011.ht
Differences were observed in the amount of drug recovered at sacrificial timepoints and rate at which drug was delivered to the target site between plaster and gel formulations of ibuprofen and diclofenac and between plaster formulations of the same drug (ibuprofen). While the amount of drug quantified at sacrificial timepoints did not necessarily determine flux rates, differences in drug distribution within the skin layers indicated where drug reservoirs were formed. These findings highlight the importance of intelligent formulation
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