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The identification of three genes pivotal for PAg recognition encoding for Vγ9, Vδ2, and butyrophilin (BTN) 3 in several non-primate types identified prospect species having PAg-reactive Vγ9Vδ2 T cells. Here, we examine the present familiarity with the molecular foundation of PAg recognition. This not just includes human Vγ9Vδ2 T cells plus the present breakthrough of BTN2A1 as Vγ9-binding protein mandatory for the PAg response but also insights attained through the identification of functional PAg-reactive Vγ9Vδ2 T cells and BTN3 when
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