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As a whole, 56 patients received FTD/TPI, among whom 24 and 32 had been addressed with monotherapy and combination therapy, respectively. The median PFS was 1.8 and 4.7months for the monotherapy and combo hands, respectively (risk ratio [HR] 0.28; 95% confidence interval [CI] 0.15-0.51; P 0.001). The median OS was 6.3 and 11.7months when it comes to monotherapy and combination hands, correspondingly (HR 0.25; 95% CI 0.13-0.48; P 0.001). CIN (class 3 or even worse) created in five (20.8%)