https://www.selleckchem.com/pr....oducts/sch-900776.ht
For vaborbactam, the following significant covariate relationships were identified CL increased with increasing height, volume of the central compartment (Vc) increased with increasing body surface area, and CL, Vc, and volume of the peripheral compartment were systematically different in Phase 1 non-infected subjects relative to Phase 3 infected patients, respectively. Visual predictive checks demonstrated minimal bias, supporting the robustness of the final models. These models were useful for generating individual PK exposures for
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