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CONCLUSIONS ARPE-19 mitochondrial purpose is managed by miR-494-3p. Raised levels of miR-494-3p in EVs introduced by ARPE-19 cells suggest diminished capability of the mitochondria within these cells. GENERAL SIGNIFICANCE EV miR-494-3p is a possible biomarker for RPE mitochondrial disorder, which plays a central role in non-neovascular age-related macular degeneration, and could be a diagnostic biomarker for keeping track of the scatter of degeneration to neighboring RPE cells when you look at the retina. V.In
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