https://www.selleckchem.com/pr....oducts/gsk3326595-ep
Results The expression of miR-34a in cartilaginous tissues and cells of osteoarthritis model was significantly higher than that in normal (p less then 0.05). After silencing miR-34a gene, the cell proliferation and proteins expression of PI3K/Akt pathway were increased, while the apoptosis rate and expression of apoptosis-related proteins were decreased. Addition of PI3K activator also evidently promoted proliferation and inhibited apoptosis. The protein expression of Bax, Cleaved caspase-3 and Cleaved caspase-9 were dramat
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