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Examine the effects of chronic oral Methylphenidate (MP) treatment on the N-Methyl-D-aspartic acid (NMDA) glutamate receptor binding in the rat brain using a previously established drinking paradigm that has been shown to deliver MP with similar pharmacokinetic profile as observed clinically. Briefly, rats were divided into three treatment groups of water, low dose MP (LD; 4/10mg/kg), or high dose MP (HD; 30/60mg/kg). Following a 3-month treatment period, some rats were sacrificed while others went through an additional 1-month abstinen
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