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Results From 2,486 articles, we selected 16 studies for analysis. EE treatment was associated with improvements in wound healing performance based on wound healing rate (mouse model weighted mean difference (WMD) = 3.55, 95% confidence interval (CI) 2.34-4.77, p less then 0.00001; rat model WMD = 17.29, 95% CI 5.75-28.82, p = 0.003; rabbit model WMD = 19.29, 95% CI 9.95-28.64, p less then 0.0001). Clinical studies also confirmed that EE could reduce healing time in hospital (WMD = -8.94, 95% CI -17.75 to -0.14, p = 0.05). Conclusion The results of t