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Lidocaine, a typical neighborhood anesthetic, has been shown to directly induce neurotoxicity in medical settings. Dexmedetomidine (DEX) is an alpha-2-adrenoreceptor agonist which has been utilized as anxiolytic, sedative, and analgesic agent that has recently found to safeguard against lidocaine-induced neurotoxicity. Nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1)/forkhead package O3 (FOXO3a) signaling is crucial for mainta