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Moreover, TIFs, either subjected to Pep 2, or silenced for αv integrin, were weakened within their capability to chemoattract cancer cells and to contract collagen matrices, displaying paid off α-smooth muscle tissue actin (α-SMA) amounts. Finally, peptide visibility of αv-expressing primary CAFs led to the downregulation of α-SMA protein also to a dramatic reduction of their particular pro-invasive capability. To conclude, the ca
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