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Predictive models are improved by the methodology adopted in this study, notably the systematic evaluation of descriptors, rather than simply using any and all available descriptors, often based empirically on in vitro experiments. Such findings also have clear relevance to a number of other fields. © 2020 Royal Pharmaceutical Society, Journal of Pharmacy and Pharmacology.in English, Spanish ANTECEDENTES Se desconoce si la lateralidad del tumor influye en la extensión anatómica y en la distribución de las metástasis en los ganglios linfá