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Importantly, there was a statistically significant difference in the proportion of these endotypes between these geographically distinct subgroups with NPs (P= .03). Droplet-based single-cell RNA sequencing further identified prominent type 2 inflammatory transcript expression C-C motif chemokine ligand 13 (CCL13) and CCL18 in M2 macrophages, as well as cystatin SN (CST1) and CCL26 in basal, suprabasal, and secretory epithelial cells. NPs from both racial groups harbor the same 2 major endotypes, which we have determined to be present in d

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