https://www.selleckchem.com/pr....oducts/Vorinostat-sa
AUC for LV contractility (ie, negative inotropic burden) was 2.2- to 3.6-fold greater for 2.0 mg/kg 10-minute IV dose than for the lower, more rapidly delivered doses. QRS complex widening by flecainide was highly correlated with the decrease in LV contractility (r = 0.890, P .0001, for all IV doses; r = 0.812, P = .01, for intratracheal flecainide). QRS complex widening in response to flecainide is strongly correlated with decrease in LV contractility. Rapid pulmonary or IV flecainide delivery reduces the negative inotropic
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