https://www.selleckchem.com/pr....oducts/brincidofovir
A novel enzyme cleavable linker for antibody-drug conjugates is reported. The 3-O-sulfo-β-galactose linker is cleaved sequentially by two lysosomal enzymes - arylsulfatase A and β-galactosidase - to release the payload in targeted cells. An α-HER2 antibody-drug conjugate synthesised using this highly hydrophilic dual-cleavable linker exhibited excellent cytotoxicity and selectivity.Living or artificial self-propelled colloidal particles show original dynamics when they interact with other objects like passive particles, interfaces
Like
Comment
Share
