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For example, is motion along the reaction coordinate diffusive, is there conformational memory, and is reduction to just one degree of freedom to represent the reaction mechanism justified? It turns out that these questions can be formulated as experimentally testable mathematical inequalities, and their application to experimental and simulated data has already led to a number of insights. I will also discuss open issues and current challenges in this fast evolving field of research.Reactions of Au+(1S,3D) and AuX+ with CH3X (

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