https://www.selleckchem.com/pr....oducts/chir-99021-ct
GRAPHICAL ABSTRACT http//cancerres.aacrjournals.org/content/canres/81/10/2714/F1.large.jpg.Inactivation of tumor-infiltrating lymphocytes (TIL) is one of the mechanisms mitigating antitumor immunity during tumor onset and progression. Epigenetic abnormalities are regarded as a major culprit contributing to the dysfunction of TILs within tumor microenvironments. In this study, we used a murine model of melanoma to discover that Tet2 inactivation significantly enhances the antitumor activity of TILs with an efficacy compara
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