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RESULTS Serum NfL levels were significantly increased in the PD group (p = 0.01, and were also related to worse cognitive performance and a cortical macro and microstructural compromise (p less then 0.05 corrected). These associations were observed both cross-sectionally and longitudinally within a one-year follow-up period. Topographically, NfL levels reflected posterior-cortical deterioration rather than frontal damage. Importantly, NfL levels were not associated with striatal SPECT-DAT uptake or β-amyloid burden. DISCUSSION Our res
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