https://www.selleckchem.com/pr....oducts/fph1-brd-6125
August Krogh pioneered a view of cardiac output that emphasised the rate of venous return, and stressed the importance of changing the filling of the 'inadequately' supplied heart, instead of changes in heart rate or cardiac inotropy. Krogh, by and large, presented this concept in three manuscripts published in 1912, which relied on innovative experimental techniques (developed in collaboration with Johannes Lindhard) as well as mathematical and physical models. In this graphical review, we revisit Krogh's original articles, demon