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In this issue of the Journal, Upson et al. assess urinary cadmium as a potential environmental influence of ovarian reserve, as measured using serum follicle stimulating hormone (FSH), in data from 1,681 women and compare three methods for modeling urinary proxy exposures - standardization, covariate adjustment (CA) and covariate adjusted standardization (CAS). Observing positive associations in all three approaches, but higher magnitude of estimates using CA compared to standardization and CAS - proposed to be the result of collider-stra
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