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Right here we demonstrated that AngII therapy triggers the reduction of intratumoral infiltrating CD4 T lymphocytes in tumor-bearing mice, escalates the accumulation of immunosuppressive granulocytes and TAMs in tumor tissue, and upregulates the expression degrees of immunosuppressive marker genetics. In inclusion, AngII/AGTR1 axis triggers cell PD-L1 appearance through a mechanism concerning increases in PD-L1 mRNA security by human antigen R (HuR), an AU-rich element (ARE)-
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