https://www.selleckchem.com/pr....oducts/smoothened-ag
Consistent with network controllability theory, co-inhibitor treatment also shifted the transcriptomic state of Ph-like ALL cells to become less like kinase-activated -rearranged (Ph+) B-ALL and more similar to prognostically favorable childhood B-ALL subtypes. Our study represents a powerful conceptual framework for combinatorial drug discovery based on systematic interrogation of synergistic vulnerability pathways with pharmacologic inhibitor validation in preclinical human leukemia models. Our study represents a po
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