https://www.selleckchem.com/pr....oducts/otub2-in-1.ht
The mRNA expression levels of 9 hub targets (all except Il1 showed significant changes during DZN treatment, and AChE activity inhibition correlated strongly with Akt1, Mapk3, Il6, Il2, and Fgf2. DZN-induced hippocampal neurotoxicity was associated with the altered activity of multiple signaling pathways (including PI3K-Akt, TNF, and apoptosis signaling). These results provided a theoretical basis for more precise elucidation of DZN neurotoxic mechanisms.Phenolic acids and tanshinones are main bioactive compounds produced in Salvia
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