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In sarcoidosis, all three monocyte subsets had significantly reduced CD200R and CD47 expression compared with healthy controls. A dichotomous distribution of CD200R was seen on classical and intermediate monocytes in the sarcoidosis population, with 14 out of 25 (56%) sarcoidosis patients having a CD200R phenotype and 11 out of 25 (44%) having a CD200R phenotype. These distinct sarcoidosis monocyte phenotypes remained consistent over time. Nonclassical monocytes, which are expanded in sarcoidosis, express very low levels of regulatory

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