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80, 95% CI = 2.87-8.02, = 2.12*10 ; OR for DLB 12.24, 95% CI = 4.95-30.24, = 5.71*10 ), which, on the basis of the impact on glucocerebrosidase activity, would be expected to be mild. The 1.5-21 male sex bias described in sporadic PD was lost in p.T369M carriers. We also showed that PD penetrance for p.L444P could reach the 15% at age 75 years. We report a large monocentric study on -PD assessing mutation-specific data on the sex distribution, penetrance, incidence, and association with dementia of the 4 most frequent deleterious variant
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