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45 mM [relative change at -133 mV; 0.45 mM sevoflurane 0.85 (interquartile range, 0.79-0.92), n = 12, p = 0.011; 1.47 mM sevoflurane 0.37 (interquartile range, 0.34-0.62), n = 5, p less then 0.001] with a half-maximal inhibitory concentration of 0.88 (95% CI, 0.40-2.2 mM. In contrast, effects on voltage-dependent channel gating were modest with significant changes only occurring at 1.47 mM [absolute change of half-maximal activation potential; 1.47 mM -7.2 (interquartile range, -10.3 to -5.8) mV, n = 5, p = 0.020]. In this study, we d
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