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Catalytic depolymerization of lignin is a challenging process due to competitive repolymerization reactions. In this paper, the oxidative depolymerization of lignin was catalyzed by a commercial laccase both in a batch experiment and in a membrane bioreactor using the same catalytic conditions. The membrane bioreactor was previously optimized to reach high permeation flux (25 L.h-1.m-2) during lignin diafiltration. While the lignin was exclusively condensed in the batch experiment leading to high molecular weight macromolecules (from 9 t