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Reprogramming Car Keys Transponders in car keys are believed to make vehicles more secure and more difficult for thieves to duplicate. The key could need to be programmed again in the case of damage or lost. You can change the programming of your key fobs at home, however you should be aware of the correct procedure. For the best results you'll need the following items: Keys Almost all modern cars require some kind of transponder fob or transponder keys to operate, providing security and protection