https://cxcrsignaling.com/inde....x.php/ror1-as1-knock
Here, we show that the liver-derived apolipoprotein M (ApoM) protects the lung and kidney from pro-fibrotic insults and that this circulating factor is attenuated in aged mice. Aged mouse hepatocytes exhibit transcriptional suppression of ApoM. This leads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P receptor 1 (S1PR1) within the vascular endothelial cells of lung and renal. Suboptimal S1PR1 angiocrine signaling causes decreased resistance to injury-indu
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