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ventricular diastolic function in different risk stratification, which has important reference value for clinical diagnosis and treatment of APE. The purpose of this study was to investigate pre-extraction variables associated with spontaneous space closure of the perma- nent second molar (PSM) following early extraction of the permanent first molar (PFM), and test an existing prediction model for the mandibular arch as the rates of spontaneous space closure are significantly lower in the mandible compared to the maxilla. Pre-extraction
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