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The role of the innate immune system in functional gastrointestinal pain disorders is unclear. We investigated the role of β-defensin-2 and gut permeability in childhood irritable bowel syndrome (IBS) and functional abdominal pain (FAP) symptom generation. Fecal β-defensin-2 (and in a subset, gut permeability) was measured in children with IBS (n= 116), FAP (n= 33), and healthy control (HC) children (n= 72). IBS and FAP patients were recruited from tertiary and primary care, and HCs were recruited from primary care. β-defensin-2 concen
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