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LN-111 enhances osteogenic differentiation of mesenchymal stem cells (MSCs) and bone tissue marrow progenitor cells (BMPCs) via the ECM receptor integrin-α1, αV, α6, and β1. LN-332 promotes osteogenic differentiation of MSCs and bone-marrow-derived MSCs (BMSCs) by α3β1/α3β3 integrin-mediated activation associated with focal adhesion kinase (FAK)/extracellular-signal-regulated kinase (ERK), Wnt5a, and bone tissue morphogenic proteins (BMP) signaling pathway

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