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To evaluate the prevalence and clinical correlates of lifetime migraine among patients with bipolar disorder (BD). In a cross-sectional study, we evaluated 721 adults with BD from the Mayo Clinic Bipolar Disorder Biobank and compared clinical correlates of those with and without a lifetime history of migraine. A structured clinical interview (DSM-IV) and a clinician-assessed questionnaire were utilized to establish a BD diagnosis, lifetime history of migraine, and clinical correlates. Two hundred and seven (29%) BD patients had a lifet