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The HPD caused increases in serum degrees of l-carnitine, indoxyl sulfate, and phenylacetylglutamine although not TMAO or p-cresyl sulfate. Urinary removal of l-carnitine, indoxyl sulfate, phenylacetylglutamine, and TMA increased because of the HPD but not TMAO or p-cresyl sulfate. Many participants had undetectable amounts of E.timonensis at baseline and just 50% during the HPD treatments, suggesting various other taxa are responsible when it comes to microbial generation of TMA in these peo