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Evidence from low-resource settings indicates that economic insecurity is a major barrier to HIV treatment adherence. Economic empowerment (EE) interventions have the potential to improve adherence outcomes among adolescents living with HIV (ALWHIV) by mitigating the effects of poverty. This study aims to assess the efficacy and cost-effectiveness of a savings-led family-based EE intervention, Suubi+Adherence, aimed at improving antiretroviral therapy (ART) adherence outcomes ALWHIV in Uganda. Adolescents (mean age 12years at enrolment;
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