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The nesting associated with the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended people inside the cohort.Commissural plication is a straightforward and helpful technique for commissural prolapse repair. But, simple plication might not work once the diseased commissure is thick or calcified. In these instances, we incise the commissure towards the annulus and bring two separate elements of the commiss