https://www.selleckchem.com/products/wp1066.html
LCN2 -/- mice have less intestinal inflammation, increased IL-22 expression, and greater adaptation as evidenced by less intestinal permeability, increased carbohydrate enzyme expression, less weight loss and less dysbiosis following 75% SBR than WT mice. The pro-inflammatory and anti-adaptive effects of LCN2 can be transferred to germ-free mice via a fecal transplant. Administration of exogenous IL-22 improves adaptation and restores the normal microbiome following 75% SBR in WT mice. CONCLUSIONS LCN2 promotes inflammation and retards i