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Nevertheless, only ILC2s, yet not TH cells, revealed increased ST2 appearance during the start of eosinophil development, which dramatically correlated using the wide range of eosinophil progenitors. In conclusion, our results suggest that airway allergen challenges with HDM activates IL-33-responsive ILC2s, TH cells, and eosinophils locally within the bone tissue marrow. Targeting the IL-33/ST2 axis in allergic conditions including asthma may be beneficial by lowering eosinophil production when