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Neurodegenerative disorders present with progressive and irreversible degeneration of the neurons. The most common neurodegenerative disorder is Alzheimer's disease (AD) affecting 50 million people worldwide in 2017, expected to be doubled every 20 years. Primarily affected by age, AD is the cause for old-age dementia, progressive memory loss, dysfunctional thoughts, confusion, cognitive impairment and personality changes. Neuroglia formerly understood as "glue" of the brain neurons consisting of macroglia (astrocytes, and oligodendrocy