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3-18. for the group received 'anlotinib with CCRT' (HR  =  0.578, 95% CI, 0.337-0.924, P  =  0.021). Overall objective response rates were considerable with a statistical difference between the two groups at 6 months (P1  =  0.027, P2  =  0.015) and 12 months (P1  =  0.012, P2  =  0.027). Overall adverse events are mitigated in combinatorial regimen than CCRT alone except the incidence of hypertension, which was higher in 'anlotinib with CCRT' group than CCRT group (P  =  0.023). Total 13 patients exhibited hand-foot skin reactions i

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