https://www.selleckchem.com/pr....oducts/pf-3644022.ht
The hypothalamic ventromedial nucleus (VMH) plays a major role in metabolic control, but the molecular mechanisms involved remain poorly defined. We analyzed the relevance of the BBSome, a protein complex composed of 8 Bardet-Biedl syndrome (BBS) proteins including BBS1, in VMH steroidogenic factor 1 (SF1) neurons for the control of energy homeostasis and related physiological processes. We generated mice bearing selective BBSome disruption, through Bbs1 gene deletion, in SF1 neurons (SF1 /Bbs1 ). We analyzed the consequence on body
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