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This article will reveal how local scientific determination and ambition, in the face of rejection by funders, navigated a path to success and to influence in national policy and international medicine. It will demonstrate that Birmingham, England's 'second city', was the key centre for cutting-edge biological psychiatry in Britain in the 1920s and 1930s. The ambitions of Frederick Mott - doyen of biochemistry, neuropathology and neuropsychiatry, until now celebrated as a London figure - to revolutionize psychiatric treatment through scien
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