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Two crucial recommendations from the analysis of the state of knowledge and potential ways forward are one, the formulation of integrative mega-projects, which span the multi-stakeholder spectrum, to ensure rapid success in harnessing the transformative power of photosynthesis and two, stipulating spatio-temporal, labour and economic criteria to stage-gate deliverables. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Experimental Biology.AIMS Aortic valve stenosis is commonly considered a degenerat