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02, = 0.3. However, higher [ C]PiB binding was associated with higher [ C]PBR28 binding among amyloid-negative ([ C]PiB composite score ≤1.5) (TSPO genotype-, age- and sex-adjusted slope 0.26, = 0.008) but not among amyloid-positive (slope -0.004, = 0.88) participants. Higher CSF soluble TREM2 ( = 0.72, = 0.01) and YKL-40 ( = 0.63, = 0.04) concentrations were associated with a higher [ C]PBR28 composite score. Higher body mass index, HOMA-IR, and hs-CRP were associated with higher [ C]PBR28 binding in brain regions where Aβ accumulation
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