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Staining of sarcomatoid carcinomas was present in 7/21 (33%) cases for claudin-4, 8/21 (38%) cases for MOC-31, and 5/21 (24%) cases for Ber-EP4. All three markers were negative in 12/21 (57%) sarcomatoid carcinomas. Sarcomatoid mesotheliomas did not stain with any of these markers. We conclude that claudin-4 has considerably greater specificity and comparable sensitivity to MOC-31 and Ber-EP4 for separating NSCLC from epithelioid malignant mesothelioma. The use of all three markers may be necessary for sarcomatoid neoplasms given their
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