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Furthermore, the end result of SERINC5 on antibody-dependent virus capture was abrogated by Nef expression. Our results indicate that SERINC5 inhibits HIV-1 infectivity by changing the conformation of gp120 on virions and/or physical masking of certain HIV-1 Env epitopes.IMPORTANCE SERINC5 is a number cell protein that prevents the infectivity of HIV-1 by a novel and poorly comprehended procedure. Here, we provide proof that the SERINC5 protein alters the conf
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