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© 2020 The Protein Society.Angiogenesis, the main system that enables vascular expansion for tissue regeneration or illness development, is normally triggered by an imbalance between air usage and demand. Here, by analyzing alterations in the transcriptomic profile of endothelial cells (ECs) under hypoxia we revealed that the repression of cellular period entry and DNA replication stand as central answers during the early adaptation of ECs to lower oxygen tension. Properly, hypoxia impo
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