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What is the central question of this study? FTO modification of M6A is associated with myocardial cell energy metabolism disorder, which has not been previously reported. What is the main finding and its importance? FTO reduced m6A level on SERCA2a mRNA through demethylation, thus promoting SERCA2a expression, maintaining calcium homeostasis, and improving energy metabolism of H/R cardiomyocytes. Energy metabolism disorder is the initial physiological link of myocardial ischemia-reperfusion injury. Fat mass and obesity-associated protein (
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