https://www.selleckchem.com/pr....oducts/kenpaullone.h
Gpx4, an enzyme that protects against PUFA-mediated lipid peroxidation, was elevated in disease and restored after GDC-0879 treatment. We demonstrate broader human disease relevance by uncovering patterns of GPX4 and Braf/Mapk pathway gene expression in tissue from patients with kidney diseases. Our studies reveal ETC-independent roles for CoQ in podocytes and point to Braf/Mapk as a candidate pathway for the treatment of kidney diseases.BackgroundMitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by da
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